Purpose: This study aimed to develop and validate a comprehensive multi-sensor integrated platform for objective assessment of skeletal muscle recovery kinetics following exercise-induced muscle damage (EIMD), combining biomechanical, thermal, and biochemical monitoring modalities. Methods: Forty elite male athletes were randomized to microwave diathermy (MWD, n = 20, 2.45 GHz, 160 W, 45 min/session) or control (n = 20) groups. Time-synchronized multi-sensor assessments at baseline, 24 h, 48 h, and 72 h post-EIMD included: biomechanical sensors (knee flexion range of motion via goniometry and isokinetic peak torque), thermal sensor (skin surface temperature via infrared thermometry), and biochemical sensor array (serum CK, IL-6, and CRP via high-sensitivity ELISA). Two-way repeated-measures ANOVA with Bonferroni correction examined group × time interactions across all sensor channels. Results: Pre-study validation confirmed high reliability across all sensor modalities. Cross-modality concordance analysis revealed significant correlations between biomechanical and biochemical recovery trajectories (isokinetic torque vs. IL-6: r = 0.73, p < 0.001; pain vs. IL-6: r = 0.68, p < 0.001). MWD intervention demonstrated accelerated recovery across all sensor channels: complete ROM recovery by 48 h (MWDG post-2 vs. baseline, p > 0.05; CG post-3 43% below baseline, p < 0.001), complete isokinetic torque restoration by 72 h (MWDG post-3 vs. baseline, p > 0.05; CG 44% below baseline, p < 0.001), and near-complete pain resolution (VAS 1.70 ± 2.50 mm, p < 0.05). Biomarker sensors demonstrated differential recovery kinetics: IL-6 normalized by 48 h (1.52 ± 0.14 pg/mL, p > 0.05 vs. baseline), CRP approached baseline by 72 h (0.73 ± 0.24 mg/L, p > 0.05), while CK remained elevated at post-3 (169.70 ± 22.58 U/L, 30% above baseline, p < 0.001), indicating incomplete myofiber membrane integrity recovery despite resolution of systemic inflammatory markers. The control group exhibited persistent deficits across all sensor channels with no clinically meaningful recovery. Conclusions: This study validated an integrated multi-sensor platform for recovery assessment. Microwave diathermy demonstrated efficacy by 72 h with complete functional recovery and inflammatory normalization (though CK remained elevated). Cross-modality concordance (r = 0.73 to 0.68) confirmed superior assessment compared to single-modality approaches. This laboratory-based methodology provides a framework for future portable sensor systems in athletic surveillance.
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