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    <item>
      <title>Effekt einer Glutaminsupplementierung auf belastungsinduzierte Veränderungen der Lymphozytenfunktion</title>
      <pubDate>Mon, 01 Jan 2001 03:28:42 +0100</pubDate>
      <link>https://sponet.de/sponet/Record/4007803</link>
      <guid>https://sponet.de/sponet/Record/4007803</guid>
      <author>Krzywkowski, K.</author>
      <author>Wolsk Petersen, E.</author>
      <author>Ostrowski, K.</author>
      <author>Kristensen, J. H.</author>
      <author>Boza, J.</author>
      <author>Klarlund Pedersen, B.</author>
      <dc:format>elektronische Zeitschrift</dc:format>
      <dc:subject>Blut</dc:subject>
      <dc:subject>Ernährung</dc:subject>
      <dc:subject>Leistung</dc:subject>
      <dc:subject>Supplementierung</dc:subject>
      <dc:subject>Theorie</dc:subject>
      <dc:format>elektronische Zeitschrift</dc:format>
      <dc:creator>Krzywkowski, K.</dc:creator>
      <dc:creator>Wolsk Petersen, E.</dc:creator>
      <dc:creator>Ostrowski, K.</dc:creator>
      <dc:creator>Kristensen, J. H.</dc:creator>
      <dc:creator>Boza, J.</dc:creator>
      <dc:creator>Klarlund Pedersen, B.</dc:creator>
      <content:encoded><![CDATA[The purpose of this study was to investigate the possible role of glutamine in exercise-induced impairment of lymphocyte function. Ten male athletes participated in a randomized, placebo-controlled, double-blind crossover study. Each athlete performed bicycle exercise for 2 h at 75% of maximum O2 consumption on 2 separate days. Glutamine or placebo supplements were given orally during and up to 2 h postexercise. The trial induced postexercise neutrocytosis that lasted at least 2 h. The total lymphocyte count increased by the end of exercise due to increase of both CD3+TCR+ and CD3+TCR+ T cells as well as CD3CD16+CD56+ natural killer (NK) cells. Concentrations of CD8+ and CD4+ T cells lacking CD28 and CD95 on their surface increased more than those of cells expressing these receptors. Within the CD4+ cells, only CD45RA memory cells, but not CD45RA+ naive cells, increased in response to exercise. Most lymphocyte subpopulations decreased 2 h after exercise. Glutamine supplementation abolished the postexercise decline in plasma glutamine concentration but had no effect on lymphocyte trafficking, NK and lymphokine-activated killer cell activities, T cell proliferation, catecholamines, growth hormone, insulin, or glucose. Neutrocytosis was less pronounced in the glutamine-supplemented group, but it is unlikely that this finding is of any clinical significance. This study does not support the idea that glutamine plays a mechanistic role in exercise-induced immune changes.
Source: Am J Physiol Cell Physiol.]]></content:encoded>
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    <item>
      <title>Wirkung von Glutaminsupplementierung auf belastungsinduzierte Veränderungen in den Lymphozytenfunktion</title>
      <pubDate>Mon, 01 Jan 2001 03:28:42 +0100</pubDate>
      <link>https://sponet.de/sponet/Record/4006542</link>
      <guid>https://sponet.de/sponet/Record/4006542</guid>
      <author>Krzywkowski, K.</author>
      <author>Petersen, E. W.</author>
      <author>Ostrowski, K.</author>
      <author>Kristensen, J. H.</author>
      <author>Boza, J.</author>
      <author>Pedersen, B. K.</author>
      <dc:format>Artikel</dc:format>
      <dc:subject>Aminosäure</dc:subject>
      <dc:subject>Ausdauer</dc:subject>
      <dc:subject>Belastung</dc:subject>
      <dc:subject>Immunität</dc:subject>
      <dc:subject>Supplementierung</dc:subject>
      <dc:subject>Zelle</dc:subject>
      <dc:format>Artikel</dc:format>
      <dc:creator>Krzywkowski, K.</dc:creator>
      <dc:creator>Petersen, E. W.</dc:creator>
      <dc:creator>Ostrowski, K.</dc:creator>
      <dc:creator>Kristensen, J. H.</dc:creator>
      <dc:creator>Boza, J.</dc:creator>
      <dc:creator>Pedersen, B. K.</dc:creator>
      <content:encoded><![CDATA[The purpose of this study was to investigate the possible role of glutamine in exercise-induced impairment of lymphocyte function. Ten male athletes participated in a randomized, placebo-controlled, double-blind crossover study. Each athlete performed bicycle exercise for 2 h at 75% of maximum O(2) consumption on 2 separate days. Glutamine or placebo supplements were given orally during and up to 2 h postexercise. The trial induced postexercise neutrocytosis that lasted at least 2 h. The total lymphocyte count increased by the end of exercise due to increase of both CD3(+)TCR alpha beta(+) and CD3(+)TCR gamma delta(+) T cells as well as CD3(-)CD16(+)CD56(+) natural killer (NK) cells. Concentrations of CD8(+) and CD4(+) T cells lacking CD28 and CD95 on their surface increased more than those of cells expressing these receptors. Within the CD4(+) cells, only CD45RA(-) memory cells, but not CD45RA(+) naive cells, increased in response to exercise. Most lymphocyte subpopulations decreased 2 h after exercise. Glutamine supplementation abolished the postexercise decline in plasma glutamine concentration but had no effect on lymphocyte trafficking, NK and lymphokine-activated killer cell activities, T cell proliferation, catecholamines, growth hormone, insulin, or glucose. Neutrocytosis was less pronounced in the glutamine-supplemented group, but it is unlikely that this finding is of any clinical significance. This study does not support the idea that glutamine plays a mechanistic role in exercise-induced immune changes.
Am J Physiol Cell Physiol 2001 Oct;281(4):C1259-65]]></content:encoded>
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