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    <item>
      <title>Reaktivierung des Epstein-Barr Virus und Erkrankung der oberen Atemwege bei Eliteschwimmern</title>
      <pubDate>Tue, 01 Jan 2002 06:44:21 +0100</pubDate>
      <link>https://sponet.de/sponet/Record/3034559</link>
      <guid>https://sponet.de/sponet/Record/3034559</guid>
      <author>Gleeson, M.</author>
      <author>Pyne, D. B.</author>
      <author>Austin, J. P.</author>
      <author>Francis, J. L.</author>
      <author>Clancy, R. L.</author>
      <author>McDonald, W. A.</author>
      <author>Fricker, P. A.</author>
      <dc:format>Artikel</dc:format>
      <dc:subject>Schwimmen</dc:subject>
      <dc:subject>Belastung</dc:subject>
      <dc:subject>Virus</dc:subject>
      <dc:subject>Infektion</dc:subject>
      <dc:subject>Atmung</dc:subject>
      <dc:subject>Organ</dc:subject>
      <dc:subject>Sportmedizin</dc:subject>
      <dc:format>Artikel</dc:format>
      <dc:creator>Gleeson, M.</dc:creator>
      <dc:creator>Pyne, D. B.</dc:creator>
      <dc:creator>Austin, J. P.</dc:creator>
      <dc:creator>Francis, J. L.</dc:creator>
      <dc:creator>Clancy, R. L.</dc:creator>
      <dc:creator>McDonald, W. A.</dc:creator>
      <dc:creator>Fricker, P. A.</dc:creator>
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      <title>Epsteinb-Barr Virusreaktivierung und Erkrankung der oberen Atemwege bei Eliteschwimmern</title>
      <pubDate>Tue, 01 Jan 2002 06:44:21 +0100</pubDate>
      <link>https://sponet.de/sponet/Record/4006879</link>
      <guid>https://sponet.de/sponet/Record/4006879</guid>
      <author>Gleeson, M.</author>
      <author>Pyne, D. B.</author>
      <author>Austin, J.</author>
      <author>Lynn Francis, J.</author>
      <author>Clancy, R. L.</author>
      <author>McDonald, W. A.</author>
      <author>Fricker, P. A.</author>
      <dc:format>Artikel</dc:format>
      <dc:subject>Sportmedizin</dc:subject>
      <dc:subject>Schwimmen</dc:subject>
      <dc:subject>Krankheit</dc:subject>
      <dc:subject>Infektion</dc:subject>
      <dc:subject>Immunität</dc:subject>
      <dc:subject>Atmung</dc:subject>
      <dc:format>Artikel</dc:format>
      <dc:creator>Gleeson, M.</dc:creator>
      <dc:creator>Pyne, D. B.</dc:creator>
      <dc:creator>Austin, J.</dc:creator>
      <dc:creator>Lynn Francis, J.</dc:creator>
      <dc:creator>Clancy, R. L.</dc:creator>
      <dc:creator>McDonald, W. A.</dc:creator>
      <dc:creator>Fricker, P. A.</dc:creator>
      <content:encoded><![CDATA[PURPOSE: The aim of this study was to investigate the relationships between latent viral shedding of Epstein-Barr virus (EBV) in saliva, upper-respiratory illness, and mucosal immune suppression in a cohort of highly trained swimmers undertaking intensive training. METHODS: Saliva was collected before selected training sessions from 14 elite male swimmers during a 30-d period of intensive training. Prior infection with EBV was determined by EBV antibody serology. Salivary IgA concentrations were measured by enzyme linked immunosorbent assay (ELISA), and EBV viral shedding (EBV-DNA) was detected by polymerase chain reaction (PCR). Symptoms of upper-respiratory illness were recorded daily. RESULTS: Eleven swimmers (79%) were seropositive for prior EBV infection. Seven EBV seropositive swimmers (64%) had EBV-DNA detected during the study period. Upper-respiratory symptoms (URS) were reported in six of seven swimmers in whom EBV-DNA was detected and in three of four swimmers with no EBV-DNA detection. No URS were reported in the EBV seronegative swimmers. There was a statistically significant relationship between EBV serology status and URS (P = 0.027). EBV-DNA was detected in saliva before the appearance of URS. Salivary IgA levels were significantly lower immediately before the URS (P = 0.01) compared with subsequent peak IgA levels and declined to pre-URS levels on average 11 d after the first appearance of URS. CONCLUSIONS: The time course of appearance of EBV-DNA in relation to URS suggests latent viral EBV shedding may be a contributing factor in the URS. The low levels of salivary IgA detected before the URS indicated transient mucosal immune suppression in the study cohort. The viral shedding may alternatively be a reflection of the altered immune control mechanisms that occur in response to intensive exercise and unrelated to the URS.]]></content:encoded>
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