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    <title>Ergebnis für Versionen - 4009019</title>
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    <item>
      <title>Beleg für Atemwegsentzündung und -behandlung bei Skisportlern mit und ohne bronchialer Hyperempfindlichkeit auf Methacholin</title>
      <pubDate>Sat, 01 Jan 2000 04:53:21 +0100</pubDate>
      <link>https://sponet.de/sponet/Record/4009019</link>
      <guid>https://sponet.de/sponet/Record/4009019</guid>
      <author>Karjalainen, E. M.</author>
      <author>Laitinen, A.</author>
      <author>Sue-Chu, M.</author>
      <author>Altraja, A.</author>
      <author>Bjermer, L.</author>
      <author>Laitinen, L. A.</author>
      <dc:format>Artikel</dc:format>
      <dc:subject>Skilanglauf</dc:subject>
      <dc:subject>Hochleistungssport</dc:subject>
      <dc:subject>Atmung</dc:subject>
      <dc:subject>Lunge</dc:subject>
      <dc:subject>Krankheit</dc:subject>
      <dc:subject>Sportmedizin</dc:subject>
      <dc:format>Artikel</dc:format>
      <dc:creator>Karjalainen, E. M.</dc:creator>
      <dc:creator>Laitinen, A.</dc:creator>
      <dc:creator>Sue-Chu, M.</dc:creator>
      <dc:creator>Altraja, A.</dc:creator>
      <dc:creator>Bjermer, L.</dc:creator>
      <dc:creator>Laitinen, L. A.</dc:creator>
      <content:encoded><![CDATA[Asthma-like symptoms, methacholine hyperresponsiveness, and use of asthma medication are prevalent in elite cross-country skiers. We quantitated mucosal inflammatory cell infiltration and tenascin expression in the subepithelial basement membrane in endobronchial biopsy specimens of the proximal airways from 40 elite, competitive skiers (mean: 17.5; range: 16 to 20 yr) without a diagnosis of asthma, in 12 subjects with mild asthma, and in 12 healthy controls, through immunohistochemistry and indirect immunofluorescence, respectively. All of the subjects were nonsmokers. T-lymphocyte, macrophage, and eosinophil counts were, respectively, greater by 43-fold (p < 0.001), 26-fold (p < 0.001), and twofold (p < 0.001) in skiers, and by 70-fold (p < 0.001), 63-fold (p < 0.001), and eightfold (p < 0.001) in asthmatic subjects than in controls. In skiers, neutrophil counts were more than twofold greater than in asthmatic subjects, and mast cell counts were not significantly different than in controls. Tenascin expression (as measured through the thickness of the tenascin-specific immunoreactivity band in the basement membrane) was increased in skiers (median: 6.7 µm; interquartile range [IQR]: 5.3 to 8.5 µm, p < 0.001) and asthmatic subjects (mean: 8.8 µm; IQR: 7.2 to 10.8 µm, p < 0.001) compared with controls (mean: 0.8 µm; IQR: 0 to 3.1 µm) and did not correlate with inflammatory cell counts. Inflammatory changes were present irrespective of asthmalike symptoms, hyperresponsiveness, or atopy. Prolonged repeated exposure of the airways to inadequately conditioned air may induce inflammation and remodeling in competitive skiers.]]></content:encoded>
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      <title>Nachweis von Entzündung der Luftwege und Zurückbildung bei Skisportlern mit und ohne bronchialer Überempfindlichkeit gegenüber Methacholin</title>
      <pubDate>Sat, 01 Jan 2000 04:53:21 +0100</pubDate>
      <link>https://sponet.de/sponet/Record/4000326</link>
      <guid>https://sponet.de/sponet/Record/4000326</guid>
      <author>Karjalainen, E. M.</author>
      <author>Laitinen, A.</author>
      <author>Sue-Chu, M.</author>
      <author>Altraja, A.</author>
      <author>Bjermer, L.</author>
      <author>Laitinen, L. A.</author>
      <dc:format>Artikel</dc:format>
      <dc:subject>Therapie</dc:subject>
      <dc:subject>Skilanglauf</dc:subject>
      <dc:subject>Pharmaka</dc:subject>
      <dc:subject>Krankheit</dc:subject>
      <dc:subject>Atmung</dc:subject>
      <dc:subject>Sportmedizin</dc:subject>
      <dc:format>Artikel</dc:format>
      <dc:creator>Karjalainen, E. M.</dc:creator>
      <dc:creator>Laitinen, A.</dc:creator>
      <dc:creator>Sue-Chu, M.</dc:creator>
      <dc:creator>Altraja, A.</dc:creator>
      <dc:creator>Bjermer, L.</dc:creator>
      <dc:creator>Laitinen, L. A.</dc:creator>
      <content:encoded><![CDATA[Asthma-like symptoms, methacholine hyperresponsiveness, and use of asthma medication are prevalent in elite cross-country skiers. We quantitated mucosal inflammatory cell infiltration and tenascin expression in the subepithelial basement membrane in endobronchial biopsy specimens of the proximal airways from 40 elite, competitive skiers (mean: 17.5; range: 16 to 20 yr) without a diagnosis of asthma, in 12 subjects with mild asthma, and in 12 healthy controls, through immunohistochemistry and indirect immunofluorescence, respectively. All of the subjects were nonsmokers. T-lymphocyte, macrophage, and eosinophil counts were, respectively, greater by 43-fold (p < 0.001), 26-fold (p < 0.001), and twofold (p < 0.001) in skiers, and by 70-fold (p < 0.001), 63-fold (p < 0.001), and eightfold (p < 0.001) in asthmatic subjects than in controls. In skiers, neutrophil counts were more than twofold greater than in asthmatic subjects, and mast cell counts were not significantly different than in controls. Tenascin expression (as measured through the thickness of the tenascin-specific immunoreactivity band in the basement membrane) was increased in skiers (median: 6.7 microm; interquartile range [IQR]: 5.3 to 8.5 microm, p < 0.001) and asthmatic subjects (mean: 8.8 microm; IQR: 7.2 to 10.8 microm, p < 0. 001) compared with controls (mean: 0.8 microm; IQR: 0 to 3.1 microm) and did not correlate with inflammatory cell counts. Inflammatory changes were present irrespective of asthmalike symptoms, hyperresponsiveness, or atopy. Prolonged repeated exposure of the airways to inadequately conditioned air may induce inflammation and remodeling in competitive skiers.]]></content:encoded>
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