Acute interleukin-6 administration impairs athletic performance in healthy, trained male runners
(Akute Interleukin-6-Administration beeinflusst die Leistung bei gesunden, trainierten Läufern)
Fatigue is an inevitable consequence of physical activity; yet its biological cause remains uncertain. During exercise, a polypeptide messenger molecule interleukin-6 (IL-6) is actively produced. Previously, the administration of recombinant IL-6 (rhIL-6) induced a heightened sensation of fatigue in healthy humans at rest. In contrast, anti-IL-6 receptor antibodies reduced the symptoms of chronic fatigue. In the present study, athletic performance during an exercise challenge consisting of a 10-km running time trial was significantly impaired in trained male runners following the administration of a low dose of rhIL-6 compared to the placebo trial.
© Copyright 2004 Canadian Journal of Applied Physiology. Human Kinetics. Alle Rechte vorbehalten.
Schlagworte: | Hormon Biochemie Sportphysiologie Sportmedizin Lauf Langstreckenlauf Leistung Ermüdung |
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Notationen: | Biowissenschaften und Sportmedizin Ausdauersportarten |
DOI: | 10.1139/h04-026 |
Veröffentlicht in: | Canadian Journal of Applied Physiology |
Veröffentlicht: |
Champaign
2004
|
Jahrgang: | 29 |
Heft: | 4 |
Seiten: | 411-418 |
Dokumentenarten: | Artikel |
Sprache: | Englisch |
Level: | hoch |